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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on practical aspects of the research design, like the recruitment and consent process, adherence, and the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers various classic table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience as well as a broad variety of betting options via virtual. The company also has several game shows that make online gambling fun and interactive. Some of these shows feature a live host, while others are hosted by famous personalities from the industry.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers to guide their decisions. They are also a good way to identify the causality between an intervention and its results. However, they shouldn't be used as a substitute for explanation studies.

The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study that includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.