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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are usually characterized by a focus on the practical aspects of study design, such as the recruitment process and consent as well as adherence to the use of commonly available equipment.

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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. Too much heterogeneity, however could cause issues with the design of the trial.

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Most Pragmatic Play slot games feature traditional themes, but also modern graphics, making them popular with both newcomers and seasoned players. They have a variety of paylines and bonus rounds and many offer progressive jackpots. They are also not particularly volatile, so you can expect to enjoy a long playing session with them.

Pragmatic Play offers a large number of games that you can play at no cost before deciding whether to pay for them. These free games are designed to play on all kinds of devices including tablets, desktops and smartphones. They are easy to navigate, and you can play them anywhere you have an internet connection. Some Pragmatic Play websites even let you test your luck while moving around with a practice mod. This helps you familiarize yourself with the game's rules and features prior to playing with real money.

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Pragmatic Play has gained a reputation for offering high-quality games and a superior user experience. Its software is accessible on mobile devices and in multiple languages. It has been recognized as one of the top casino gaming platforms despite its relatively young age. Wolves is one of the most recent releases, a 5-reel slot machine that has a high RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They can also be used to assess the causality of an intervention with its outcomes. They should not, however be used to replace explanation studies.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a pragmatic trial, including recruitment, design and delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.

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